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Journal: bioRxiv
Article Title: Proteomic profiling reveals pleiotropic antimetabolite activity of triciribine in acute lymphoblastic leukemia
doi: 10.64898/2026.03.13.710465
Figure Lengend Snippet: A , UMAP visualization of drug sensitivity profiles for 528 compounds tested across 43 ALL cell lines. Each point represents a compound, positioned based on similarity of killing profiles. B , sDSS values for triciribine and PI3K-Akt-mTOR pathway inhibitors across 43 ALL cell lines. The dashed line indicates sDSS = 8. The mean sDSS value for each inhibitor is indicated by an ‘×’ or a larger dot. Akt inhibitors are indicated in red. C , Pairwise Spearman correlation analysis of drug sensitivity profiles for PI3K-Akt-mTOR pathway inhibitors across 43 ALL cell lines. Akt inhibitors are indicated in red. D , Immunoblot analysis of phosphorylated Akt (Ser473), total Akt, and the loading control SOD1 in ALL-SIL and P12-ICHIKAWA cells following treatment with indicated concentrations or durations of triciribine.
Article Snippet: Primary antibodies included ADK (AM8619b-ev; Nordic Biosite),
Techniques: Western Blot, Control